Kinetics of plasma von Willebrand factor in acute myocardial infarction patients: a meta-analysis

// Xia Wang 1 , Junyu Zhao 2 , Yong Zhang 3 , Xiujuan Xue 4 , Jie Yin 3 , Lin Liao 2 , Cuiping Xu 4 , Yinglong Hou 3 , Suhua Yan 3 and Ju Liu 1 1 Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014 Shandong, China 2 Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014 Shandong, China 3 Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014 Shandong, China 4 Department of Nursing, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014 Shandong, China Correspondence to: Ju Liu, email: ju.liu@sdu.edu.cn Keywords: von Willebrand factor, kinetics, acute myocardial infarction, meta-analysis Received: May 16, 2017      Accepted: July 26, 2017      Published: August 09, 2017 ABSTRACT Previous studies have shown a variation in plasma level of von Willebrand factor (vWF) in acute myocardial infarction (AMI) patients but with contentious results. In this study, we performed a meta-analysis to evaluate the kinetics of plasma vWF after AMI. A total of 11 qualified studies were obtained through systematical search in PubMed, Web of science, Cochrane Library database and CNKI, followed by search of reference lists, involving 519 AMI patients and 466 non-AMI controls. The standard mean difference (SMD) and 95% confidence intervals (95% CI) were calculated using random-effects model. Results indicated that the plasma vWF was significantly increased in the first several hours after onset of AMI (SMD = 1.94, 95% CI = 1.39–2.48, P 6 h, elevated vWF was found in all 7 days except day 1. Our findings determined the kinetics of plasma vWF after AMI, and might provide a new insight in monitoring AMI progression.