Легочная гипертензия и состояние правых отделов сердца у больных бронхиальной астмой

The pulmonary haemodynamics parameters, the right heart condition and their relationships to the endothelium vessel-regulating function in bronchial asthma (BA) patients were studied in this article. The work proved a high informative value of echocardiography for chronic cor pulmonale detection. Correlations between pulmonary hypertension, the disease severity and the respiratory failure severity were found. The BA patients showed disorders of the functional activity of the brachial artery endothelium which were related to pulmonary haemodynamics changes, the right ventricle wall thickness, and the right atrium end diastolic size. Disorders of the endothelium-dependent dilation demonstrated reduced abilities of the endothelium to synthe­size vasodilating substances in BA patients.