Preparation of Silica-Based Superficially Porous Silica and its Application in Enantiomer Separations: a Review

Chromatographic substrate material, as a carrier of chromatographic stationary phases, plays a vital role in defining its chromatographic characteristics, including column efficiency, stability, peak capacity and so on. In recent years, superficially porous silica (SPS) was widely valued for its excellent performance in improving the column efficiency due to its special structural properties, which was considered as a real substitute for fully porous SiO2 (FPS) and had been used to develop a new generation of highly efficient stationary phase. To help researchers better understand the SPS and further promote its application and development in the field of chromatography, the rapid separation mechanism, preparation method and its applications in the rapid separation and analysis of enantiomers were systematically introduced, and the development prospects of SPS were also prospected in this paper.