Ag(I)-Mediated Hydrogen Isotope Exchange of Mono-Fluorinated (Hetero)arenes

An efficient approach to install deuterium into mono-fluorinated (hetero)arenes by Ag2CO3/Sphos mediated HIE protocol with D2O as deuterium source has been disclosed. This method showed specific site-selectivity of deuteration at α position of fluorine atom, which is complementary to the existing transition-metal catalyzed HIE process.