2,4-thiazolidinediones as potent and selective human β3 agonists
2001
Abstract Methylsulfonamide substituted 2,4-thiazolidinedione 22c is a potent (EC 50 =0.01 μM, IA=1.19) and selective (more than 110-fold over β 1 and β 2 agonist activity) β 3 agonist. This compound has also been proven to be active and selective in an in vivo mode.
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