Inflammatory tissue damage in chronic destructive arthritis is regulated by FHL2

Four-and-a-half LIM 2 (FHL2) is a mediator of protein interactions involved in cellular processes that are of relevance for the activation of mesenchymal cells. It interacts with integrins, focal adhesion-and mitogen-activated kinases, transcription factor AP-1 and is involved in TRAF6-dependent signalling. We analysed the function of FHL2 in chronic inflammatory arthritis. The expression of FHL2 in synovial tissues from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) and in destructive arthritis of human tumour necrosis factor transgenic (hTNFtg) mice was analysed by immunohistochemistry. …