Biomedical imaging with the Medipix2 semiconductor detector at UniAndes

A set-up for X-Ray Imaging was developed using a Medipix2 MXR detector, a PHYWE X-Ray Unit, and a Step Motor as sample holder. An equalization and raw acquisitions were also performed. As the Beam Hardening effect arose in the radiographies, it was necessary to correct the images through a Direct Thickness Calibration. The result was the acquisition of high resolution (~μm) images from 10 to 35 keV with small exposure times. After the characterization of the set-up, it was used to image motionless and living tissue. Its feasibility to image samples bigger than its sensitive part and to use it for vascular imaging was also studied. Some of the tests were validated using Monte Carlo simulations (ROSI). The high granularity of the detector makes it suitable for micro-CT. Medipix2 has a very fast response (~ hundreds of nanoseconds) and high sensibility. These features allow obtaining nearly in-vivo high resolution (55μm* 55μm) images.