The Safety of Intraocular Linezolid in Rabbits

RESULTS. There were no statistically significant differences in the electroretinograms obtained between the linezolid-injected eyes and the control eyes. Histopathology showed no changes in the study eyes compared with the control eyes. CONCLUSIONS. Preservative-free linezolid is nontoxic to the retinas of rabbits when injected intravitreally, and this route can therefore be considered for the administration of linezolid in the treatment of endophthalmitis. (Invest Ophthalmol Vis Sci. 2010;51:3115‐3119) DOI:10.1167/iovs.09-4244