Differences in Functional Loss Associated with Ganglion Cell Complex Thinning between Patients with Glaucoma and Postoperative Macular Hole

AbstractPurpose: To compare the changes in the photopic negative response (PhNR) of the focal macular electoretinogram (fmERG) caused by a thinning of the ganglion cell complex (GCC) between patients with open angle glaucoma (OAG) and after successful macular hole (MH) surgery.Methods: Twenty-seven eyes of 27 OAG patients (OAG group), 28 eyes of 28 MH patients (MH group) and 23 eyes of 23 normal volunteers (control group) were studied. The OAG patients had early stage of glaucoma. The MH patients had been successfully treated with vitrectomy 12 months earlier. The averaged GCC thickness in the macular area (15 degree in a diameter) was measured by SD-OCT. The fmERGs were elicited by a 15° stimulus centered on the fovea.Results: The GCC was significantly thinner in the OAG and MH groups than in the control group (p < 0.0001). The PhNR amplitude and PhNR/b-wave amplitude ratio were significantly reduced in the OAG group compared to the control (p < 0.0001), while no significant reduction of the PhNR amplitu...