Glutamate receptors in blood elements and bone marrow megakaryocytes

Glutamate is one of the primary endogenous amino acids of the Central Nervous System (CNS). Οver the last years research has proven the existance of glutamate subunit receptors in additional non-neuronal tissues outside CNS. In this review, we indicate the distribution of glutamate subunit receptors in peripheral blood elements, as well as in bone marrow cells, as presented in up to date literature. Although the exact significance of glutamate subunit receptors presence in peripheral tissues is not quite clear, it is of no doudt that more research is needed in order to define its purpose and its possible therapeutical role outside CNS.