Multimodal imaging comparison of polypoidal choroidal vasculopathy between Asian and Caucasian population.

Abstract Purpose : Differences in multimodal imaging features between Asians and Caucasians eyes may contribute to our understanding of the etiology of the polypoidal choroidal vasculopathy (PCV). The purpose of this study is to compare the multimodal imaging features of Asian and Caucasian eyes with PCV. Design : Cross-sectional, retrospective, multicenter, observational case series Methods : Consecutive treatment naive patients diagnosed with PCV based on indocyanine green angiography (ICGA) in accordance to published guidelines. Demographic and multimodal imaging findings based on color fundus photography, spectral domain optical coherence tomography, fluorescein angiography and ICGA were graded. Results : A total of 250 participants with PCV (128 Asians vs 122 Caucasians) were included. Asians presented with lower BCVA (0.7 ± 0.6 vs 0.4 ± 0.3 logMAR, p Conclusions : Multimodal imaging analysis revealed ethnic differences in disease characteristics of PCV, suggesting pathophysiologic mechanism of the disease vary based on ethnicity.