NCO-11TUMOR VOLUMETRIC AND TEXTURAL FEATURE PREDICTORS OF NEUROCOGNITIVE IMPAIRMENT IN PATIENTS WITH TEMPORAL LOBE GLIOMA

BACKGROUND: To determine whether computationally derived image-based textural and volumetric tumor features can predict cognitive impairment in patients with temporal lobe glioma. METHODS: Treatment naive patients with glioma (n = 69; 64% glioblastoma; 74% left temporal) completed neurocognitive testing [WAIS-III Digit Span (DS); Controlled Oral Word Association (COWA); HVLT-R Total Recall; Trail Making Test A & B (TMT)]. Demographically adjusted scores that were at or below 0.74). Volumetric and textural tumor features appear predictive of neurocognitive impairment in patients with glioma, with inclusion of textural indices conveying at least marginal improvement in classification accuracy.