Diagnosis and treatment progress of primary bone lymphoma

Primary bone lymphoma (PBL) is rare and has no specific clinical features. A mouth-eaten pattern of bone destruction in metaphysic or subchondral bone and a large soft-tissue mass with little cortical destruction are important imaging features of primary bone lymphoma. The final diagnosis mainly depends on the histopathological features and the expression of specific proteins showing by immunohistochemical staining. It bears a good outcome after radiation and chemical therapy. The operation is not a routine therapy method. So, it is important to make accurate diagnosis before radiation and chemical therapy. In this article, we reviewed the clinical diagnosis, treatment, and prognosis of primary bone lymphoma. Key words: Osteolysis, essential; Lymphoma; Diagnosis and treatment; Evolve progress