FOXO3a Activation by HDAC Class IIa Inhibition Induces Cell Cycle Arrest in Pancreatic Cancer Cells

Makoto Usami,Shohei Kikuchi,Kohichi Takada,Michihiro Ono,Yusuke Sugama,Yohei Arihara,Naotaka Hayasaka,Hajime Nakamura,Yuuki Ikeda,Masahiro Hirakawa,Makoto Yoshida,Koji Miyanishi,Masayoshi Kobune,Junji Kato

FOXO3a Activation by HDAC Class IIa Inhibition Induces Cell Cycle Arrest in Pancreatic Cancer Cells

2020

Makoto Usami
Shohei Kikuchi
Kohichi Takada
Michihiro Ono
Yusuke Sugama
Yohei Arihara
Naotaka Hayasaka
Hajime Nakamura
Yuuki Ikeda
Masahiro Hirakawa
Makoto Yoshida
Koji Miyanishi
Masayoshi Kobune
Junji Kato

ObjectivesPancreatic cancer (PC) is highly aggressive with multiple oncogenic mutations. The efficacy of current chemotherapy is poor, and new therapeutic targets are needed. The forkhead box (FOX) proteins are multidirectional transcriptional factors strongly implicated in malignancies. Their expre

Keywords:

Endocrinology
Pancreatic cancer
Cell cycle checkpoint
Biology
Internal medicine
Cancer research
Diabetes mellitus
Transcription factor
Cancer
Chemotherapy
Forkhead Box

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