Efficacy and Tolerability of Levodropropizine and Clobutinol in Elderly Patients with Nonproductive Cough
1997
In a double-blind, randomised, clinical trial involving 191 elderly patients of either gender affected by nonproductive cough, the therapeutic efficacy and tolerability of oral levodropropizine and Clobutinol (60mg three times daily for 3 days, for both agents) were evaluated. Efficacy was assessed by analysing cough intensity, the number of coughing spells in the 5 hours post-treatment, and night awakenings due to cough; tolerability was evaluated by analysing laboratory data, vital signs, dyspnoea and any adverse event occurring during the clinical trial, including the presence or absence of somnolence.
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