PI3Kγ is required for NMDA receptor–dependent long-term depression and behavioral flexibility
2011
This study examines the contribution of a specific phosphatidylinositol 3-kinase (PI3K) isoform, namely PI3Kγ, to hippocampal synaptic plasticity and behavior. The authors find that the loss of PI3Kγ can specifically impair NMDA receptor–mediated long-term depression and cognitive functions that rely on behavioral flexibility.
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