Effect of different application time of intravenous immune globulin on fever clearance time and coronary artery lesion of Kawasaki disease

Objective To investigate the application of gamma globulin in different time on tever clearance time and coronary artery lesion of patients with Kawasaki disease. Methods Ninety-six patients with Kawasaki disease from February 2015 to March 2016 were selected according to the application of gamma globulin in different time, and they were divided into three groups, with 32 cases in each group. The early group, middle group and late group was given gamma globulin treatment respectively on 1-4 d, 5-9 d, 10 d after the onset. Clinical symptoms subsided time, gamma globulin non response and other complications occurring before and after the treatment and blood routine indexes of the three groups were compared. Results The limbs swelling subsided time in late group was less than that of the early group, the rash subsided time in late group was less than that of the early group, the mucosal hyperemia subsided time in early group was less than the mid and late group, the lymph node reduction time in early group was less than that of the middle group and late stage group, the differences were significant (P<0.05). The fever subsided time in late group was longer than the that of early group and middle group, that of the middle group was longer than that of the early group. The coronary artery ectasia occurrence rate was higher in the late group than that of the early and middle group, the differences were significant (P<0.05). The incidence of gamma globulin no reaction rate in early group was significantly higher than that in the middle group and late group, the differences were significant (P<0.05); after treatment, the blood routine indexes of the three groups significantly improved, the differences were significant (P<0.05). Conclusions Treating Kawasaki disease during the onset 5-9 d with immunoglobulin in children has curative effect, it can shorten the clinical symptoms subsided and reduce incidence of coronary artery lesion. Key words: Immunoglobulin; Kawasaki disease; Fever disappearing time; Coronary artery lesion