Research: Genetics Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility

Bruno Guigas,J. E. de Leeuw van Weenen,N. van Leeuwen,Annemarie M. Simonis-Bik,T. W. van Haeften,G. Nijpels,Jeanine J. Houwing-Duistermaat,M. Beekman,Joris Deelen,Michaela Diamant,Mark H. H. Kramer,Robert J. Heine,Gonneke Willemsen,J.M. Dekker,Elisabeth M. W. Eekhoff,Hanno Pijl,E.J.C. de Geus,P.E. Slagboom

Research: Genetics Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility

2014

Bruno Guigas
J. E. de Leeuw van Weenen
N. van Leeuwen
Annemarie M. Simonis-Bik
T. W. van Haeften
G. Nijpels
Jeanine J. Houwing-Duistermaat
M. Beekman
Joris Deelen
Michaela Diamant
Mark H. H. Kramer
Robert J. Heine
Gonneke Willemsen
J.M. Dekker
Elisabeth M. W. Eekhoff
Hanno Pijl
E.J.C. de Geus
P.E. Slagboom

Aims Modulation of dopamine receptor D2 (DRD2) activity affects insulin secretion in both rodents and isolated pancreatic b-cells. We hypothesized that single nucleotide polymorphisms in the DRD2/ANKK1 locus may affect susceptibility to Type 2 diabetes in humans.

Keywords:

ANKK1
Insulin
Secretion
Type 2 diabetes
Dopamine receptor D2
Locus (genetics)
Single-nucleotide polymorphism
Genetics
Endocrinology
Biology
Diabetes mellitus
Internal medicine
sex specific
insulin secretion

Correction
Cite
Save
Machine Reading By IdeaReader

References

Citations