MDR1 gene C1236T and C6+139T polymorphisms in the Russian population: Associations with predisposition to lymphoproliferative diseases and drug resistance

Study of MDR1 polymorphism in intron 6 and exon 12 of healthy individuals and patients with chronic lymphoproliferative diseases showed that the presence of mutant 6+139T allele is a factor determining resistance to lymphoproliferative diseases. Comparison of genotyping results in 53 patients and the data on the efficiency of drug therapy showed no significant associations of C1236T and C6+139T genotypes with drug resistance.