Protein Kinase C ε Expression in Platelets from Patients with Acute Myocardial Infarction

Objective Platelets play crucial roles in the pathophysiology of thrombosis and myocardial infarction. Protein kinase C e (PKCe) is virtually absent in human platelets and its expression is precisely regulated during human megakaryocytic differentiation. On the basis of what is known on the role of platelet PKCe in other species, we hypothesized that platelets from myocardial infarction patients might ectopically express PKCe with a pathophysiological role in the disease.