In vitro regulation of osteoclast generation: A cost- effective strategy to combat osteoporosis with natural antioxidants and polyphenols like EGCG

Osteoporosis has been shown to be associated with elevated levels of TNF-α and intracellular reactive oxygen species (ROS). ROS is actively related to production of TNF-α, which in turn, leads to activation of bone markers, thereby resulting in accelerated osteoclast differentiation leading to osteoporosis. (-)-Epigallocatechin-3-gallate (EGCG), one of the most potent polyphenol, an active ingredient of green tea (Camellia sinensis), has earlier been reported to have potent