Characteristics of COVID-19 Patients Admitted to a Tertiary Care Hospital in Pune, India, and Cost-Effective Predictors of Intensive Care Treatment Requirement
2021
Importance: Description of the range of clinical-laboratory characteristics of Indian COVD-19 patients. Accurate prediction of requirement for ICU treatment based on routine tests at presentation can advise policy to triage patients into appropriate facilities and save resources.
Objective: To study associations of severity of disease and need for ICU treatment in COVID-19 patients.
Design: A retrospective study of clinical course in 800 hospitalized COVID-19 patients, and a predictive model of need for ICU treatment.
Setting: A dedicated COVID-19 tertiary care hospital in Pune, India (8th April to 15th June 2020).
Participants: Eight hundred consecutive patients admitted with confirmed COVID-19 disease.
Main outcome: Clinical and laboratory associations of severity of disease, and predictors of need for ICU management.
Results: Average age was 41 years, 16% were <20 years of age, 55% were male, 50% were asymptomatic and 16% had at least one comorbidity. Using MoHFW India severity guidelines, 73% patients had mild, 6% moderate and 20% severe disease. Severity was associated with higher age, symptomatic presentation, elevated neutrophil and reduced lymphocyte counts and elevated inflammatory markers. Seventy-seven patients needed ICU treatment: they were older (56 years), more symptomatic and had lower SpO2 and abnormal chest X-ray and deranged hematology and biochemistry at admission. A model trained on the first 500 patients, using above variables predicted need for ICU treatment with sensitivity 80%, specificity 88% in subsequent 300 patients; exclusion of expensive laboratory tests did not affect accuracy.
Conclusion and relevance: In the early phase of COVID- 19 epidemic, a significant proportion of hospitalized patients were young and asymptomatic. Need for ICU treatment was predicted by simple measures including higher age, symptomatic onset, low SpO2 and abnormal chest X-ray. We propose a cost-effective model for referring patients for treatment at specialized COVID-19 hospitals.
Funding Statement: This research study was funded by Symbiosis International (Deemed University), Pune through its internal funds.
Declaration of Interests: The authors declare no competing interests.
Ethics Approval Statement: All patients signed a written informed consent at the time of admission which permitted use of anonymized data for research. The Institutional Research Committee (IRC) of Symbiosis Medical College for Women gave necessary approvals.
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