Critical Care P-002 : A Comprehensive Analysis for Clinical Outcomes in Patients with Cancer Admitting Intensive Care Unit

Objective Until recently, studies on long- term outcomes of critically ill patients with cancer have been mainly restricted to specific subgroups of patients. This study aims to evaluate the long-term clinical outcomes of patients who received intensive care unit treatment for 5 years using the Korean nationwide data. Method All patients >18 year of age having ICU admission were enrolled from the claims data from the Health insurance review and assessment service (HIRA) from Jan 2008 to Dec 2010. Enrolled patients were followed up to Dec 2015. We analyzed clinical outcomes including mortality admitting to ICU. Critically ill patients categorized into four subgroups; patients without cancer, with solid cancer except lung, with lung cancer and with hematologic malignancies. Result Of all critically ill patients (n= 323,765) admitted to the intensive care unit, the proportion of cancer patients continued to increase from 21.5% in 2008 to 27.8% in 2010. Critically ill patients with cancer showed higher ICU mortality (18.6%) than patients without cancer (13.2%, P-value <0.001). There was no difference in ICU mortality at day 28 among patients without cancer (14.5%) and with cancer which was not lung cancer or hematologic malignancies (14.3%, P-value = 0.28). Hazard rates for the ICU mortality at 5 years were 1.90 (95% confidence interval 1.87-1.94) in lung cancer, 1.44 (95% CI, 1.43-1.46) in other solid cancers, and 3.05 (95% CI, 2.95-3.16) in hematologic malignancies compared to patients without cancer. Conclusion This study show that in the short term, the outcomes of critically ill patients having cancer were not significantly different from that of general patients, except for lung cancer and hematologic malignancies. However, long-term survival rate of cancer patients was significantly worse than that of general critical patients.