Metabolic activity to predict clinical response and prognosis in esophageal adenocarcinoma patients treated with bimodality.

127Background: Patients with localized esophageal adenocarcinoma (L-EAC) who are not suitable for surgery receive definitive chemoradiation. However, there are no biomarkers or imaging variables to predict clinical complete response (cCR; negative bx and physiologic PET post chemoradiation) or prognosticate favorable overall survival (OS). We analyzed tumor metabolic activity by standardized uptake value (SUV) or total lesion glycolysis (TLG). Methods: 266 patients with L-EAC, who declined or were unsuitable for surgery, were analyzed. Cox proportional hazards regression model for OS was analyzed using categorized SUV (low; < 6.5, moderate; 6.5-12.9, or high; ≥12.9) or TLG (low; < 24.2, moderate; 24.2-82.6, or high; ≥82.6). Logistic regression model for cCR was analyzed using categorized SUV (low; < 5.4 or high; ≥5.4) or TLG (low; < 27.0 or high; ≥27.0). Results: Mean SUV and TLG were 12.8 ± 10.7 and 209 ± 376.8, respectively. Both SUV and TLG were significantly associated with the length of the tumor (p ...