Il trattamento della depressione bipolare: un problema di difficile soluzione

Objective The burden of bipolar depression is greater than that of mania as reflected by the fact that patients spend more time in depressive phase (Fig. 1) and display greater impairment in social and family life and at work. Despite the substantial burden associated with bipolar depression, options for treatment are limited, and management represents a major clinical challenge. This study reviews current evidence regarding efficacy and safety of antidepressants and of alternative treatments for bipolar depression.