Predictive significance of thymidylate synthase and dihydropyrimidine dehydrogenase levels in patients with completely resected colorectal cancer receiving adjuvant 5-fluorouracil therapy

3629 Background: Cytotoxic effect of 5-FU is mediated through competitive binding to thymidylate synthetase (TS), leading to thymine depletion. 5-FU is catabolized by dihydropyrimidine dehydrogenas...