N ew C9-monoterpenoid Alkaloids Featuring a Rare Skeleton with Anti-inflammatory and Anti-viral Activities from Forsythia suspensa.

Forsyqinlingines C ( 1 ) and D ( 2 ), two C 9 -monoterpenoid alkaloids bearing a rare skeleton, were isolated from the ripe fruits of Forsythia suspensa . Their structures, including absolute configurations, were fully elucidated by extensive spectroscopic data and ECD experiments. The plausible biogenetic pathway for compounds 1 and 2 was also proposed. In vitro , two C 9 -monoterpenoid alkaloids showed anti-inflammatory activity performed by the inhibitory effect on the release of β -glucuronidase in rat polymorphonuclear leukocytes (PMNs), as well as anti-viral activity against influenza A (H1N1) virus and respiratory syncytial virus (RSV).