LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

Jian Luo,Zhengfeng Yang,Yu Ma,Zhiying Yue,Hongyu Lin,Guojun Qu,Jinping Huang,Wentao Dai,Chenghai Li,Chunbing Zheng,Leqin Xu,Huaqing Chen,Jiqiu Wang,Dali Li,Stefan Siwko,Josef M. Penninger,Guang Ning,Jianru Xiao,Mingyao Liu

LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

2016

Jian Luo
Zhengfeng Yang
Yu Ma
Zhiying Yue
Hongyu Lin
Guojun Qu
Jinping Huang
Wentao Dai
Chenghai Li
Chunbing Zheng
Leqin Xu
Huaqing Chen
Jiqiu Wang
Dali Li
Stefan Siwko
Josef M. Penninger
Guang Ning
Jianru Xiao
Mingyao Liu

LGR4 has been identified as a new receptor for RANKL in bone cells where it opposes RANK signaling to inhibit osteoclasts differentiation, and its therapeutic targeting promotes reduced bone loss in three mouse models of osteoporosis.

Keywords:

RANK Ligand
Immunology
Bone remodeling
Osteoporosis
RANKL
Osteoclast
Signal transduction
Bone resorption
Medicine
Bone cell

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