Association between single-nucleotide polymorphisms of rs11833579/rs12425791 in Ninjurin 2 gene and ischemic stroke in Chinese Han population: evidence from a Meta-analysis

Objective To study the association between single-nucleotide polymorphisms (SNPs) of rs11833579/rs12425791 in Ninjurin 2 (NINJ2) gene and risk of ischemic stroke in Chinese Han population. Methods PubMed, CBM, The Cochrane Library, CNKI, CBM, VIP and Wanfang Data were searched from inception to August 2016 to collect case-control studies about SNPs of rs11833579/rs12425791 in NINJ2 gene and risk of ischemic stroke in Chinese Han population. Then, Meta-analysis was performed using Stata 12.0 software to extract the data and assess the risk of bias of included studies. This Meta analysis revealed the association between SNPs of rs11833579/rs12425791 and ischemic stroke. Results Eleven independent publications, including 6125 cases and 6067 controls for rs1183379, and 5989 cases and 6145 controls for rs12425791, were chosen. Overall, large artery atherosclerotic ischemic stroke risk was associated with rs11833579 A allele when all studies were pooled into the Meta-analysis [AA/(GA+GG): OR=1.594, 95%CI: 1.155-2.201, P=0.05; AA/GG: OR= 1.731, 95%CI: 1.240-2.416, P=0.001]. However, rs12425791 was not associated with increased stroke risk in any genetic models. No publication bias was found in our Meta-analysis by Egger's and Begg's test. Sensitivity analysis confirmed the stability of results. Conclusion The rs11833579 SNPs may be a susceptibility marker of large artery atherosclerotic of ischemic stroke in Chinese Han population and further studies are warranted to verify this association. Key words: Ischemic stroke; Ninjurin 2; Polymorphism; Meta-analysis