Semantic segmentation of multispectral photoacoustic images using deep learning.

Photoacoustic imaging has the potential to revolutionise healthcare due to the valuable information on tissue physiology that is contained in multispectral photoacoustic measurements. Clinical translation of the technology requires conversion of the high-dimensional acquired data into clinically relevant and interpretable information. In this work, we present a deep learning-based approach to semantic segmentation of multispectral photoacoustic images to facilitate the interpretability of recorded images. Manually annotated multispectral photoacoustic imaging data are used as gold standard reference annotations and enable the training of a deep learning-based segmentation algorithm in a supervised manner. Based on a validation study with experimentally acquired data of healthy human volunteers, we show that automatic tissue segmentation can be used to create powerful analyses and visualisations of multispectral photoacoustic images. Due to the intuitive representation of high-dimensional information, such a processing algorithm could be a valuable means to facilitate the clinical translation of photoacoustic imaging.