IDDF2020-ABS-0043 Interval time between gastric preparation and magnetic-controlled capsule endoscopy: a randomized controlled trial

Background To investigate the best interval time between gastric preparation and magnetic-controlled capsule endoscopy by comparing the effect of various interval time on image quality of stomach, safety, tolerance and positive lesions through a randomized controlled trial. Methods 80 patients referred for MCE from Jan. 2018 to Dec. 2018 were randomly assigned to three groups, interval time with 30 minute and less (A), 30 to 60 minutes (B) or 60 minutes and more (C). All patients fasted for at least 8 hours before MCE and administrated with dimethicone, pronase and sodium bicarbonate. Cleanliness and visualization scores, safety, tolerability, additional water required and diagnostic sensitivity were compared. A multi-factor analysis of cleanliness and visualization scores was conducted. Results The total cleanliness scores were (mean±SD) 20.44±2.61 (A), 20.96±1.68 (B), and 20.56±2.90 (C). The total visualization scores (mean±SD) were 16.33±2.01 (A), 16.41±1.50 (B), and 16.07±1.96 (C). There was no statistical difference among groups A, B and C (P>0.05). MCE detected positive findings in 16 (59.3%), 18(66.7%) and 15 (55.6%) patients in group A, B and C respectively, with no significant difference between groups (P>0.05). Additional water required during MCE were (mean±SD) 107.41±70.31 mL(A),46.30±39.04 mL(B),79.63±65.43 mL(C), and it was much less in group B than the other two groups (P=0.003). There was a negative correlation between cleanliness and visualization scores and the infection of H. pylori (rs=-0.326, P=0.003 and rs=-0.235, P=0.035). Conclusions Patients administrated with dimethicone, pronase and sodium bicarbonate 30 minute and less, 30 to 60 minutes, 60 minutes and more were not statistically different in cleanliness, visualization and positive rates. But groups of 30 to 60 minutes got the least supplement of water during MCE, and it may be the best interval time between gastric preparation and MCE.