834 Neurocircuitry and Neurochemistry of Cyclic Vomiting Syndrome

structural changes in salience (which determines the relevance of internal and external information) and central autonomic networks in IBS are correlated with differences in myelopoetic processes and gene expression in PBMCs, consistent with increased SNS modulation of the peripheral immune system. 2. Regional functional changes in the salience network are correlated with expression of pro inflammatory genes, suggesting that primed monocytes migrate to the brain, inducing structural and functional changes in brain regions involved in visceral hypersensitivity and increased anxiety.