Progress of Acupuncture and Moxibustion Research on the Signal Transduction Pathways Involved in Cell Apoptosis in Myocardial Ischemia Reperfusion Injury

: Myocardial cell apoptosis is very common in the clinic, and is caused by myocardial ischemia reperfusion injury (MIRI). There are different degrees of cell apoptosis in MIRI. However, initiation of the signal transduction mechanism of myocardial cell apoptosis is unclear. The present research confirmed that acupuncture and moxibustion are effective interventions for cell apoptosis in MIRI through three approaches:the death receptor pathway, mitochondrial pathway and endoplasmic reticulum pathway. In this paper, the authors summarize the mechanism characteristics of acupuncture and moxibustion in MIRI cell apoptosis, and discuss the signal transduction pathways involved in the effects of acupuncture and moxibustion in MIRI cell apoptosis, in order to provide new ideas and evidence for the clinical application of acupuncture and moxibustion to prevent cell apoptosis in MIRI.