Associations between HIV Status Disclosure, Social Support, and Adherence to and Antiretroviral Therapy in Adults Patients with HIV/AIDS

Background: Antiretroviral therapy (ART) has been successful in increasing the life span and quality of life of people living with HIV. The success of antiretroviral treatment can be assessed from the patient's compliance in taking the drugs prescribed by the doctor at the right time and at the right dose. Disclosure of HIV status and social support are factors associated with adherence to antiretroviral therapy (ART). This study aims to estimate the magnitude of disclosure of HIV status and social support with antiretroviral therapy adherence to adult patients with HIV/AIDS with a meta-analysis study. Subjects and Method: This was a systematic review and meta-analysis conducted using PRISMA flow diagrams. Article searches were conducted through journal databases including: Google Scholar, PubMed, Springer Link, Clinical key and ProQuest. The articles used in this study are articles that have been published from 2010-2021. The keywords to search for articles are as follows: "disclosing HIV and antiretroviral adherence", "Social Support or family support and antiretroviral adherence". The inclusion criteria were full text with cross-sectional study design, articles in English, multivariate analysis with adjusted odds ratio. Eligible articles were analyzed using the Revman 5.4 application. Results: A meta-analysis of 9 observational studies showed that patients who disclosed their HIV status increased adherence to antiretroviral therapy 2.3 times compared to patients who did not disclose significantly (aOR= 2.36 95% CI= 1.75 to 3.19; p< 0.001). A meta-analysis of 9 observational studies showed that patients who received social support significantly increased adherence to antiretroviral therapy 1.4 times compared to patients who did not have support (aOR= 1.46; 95% CI= 1.08 to 1.97; p= 0.010). Conclusion: Disclosure of HIV status and social support improves adherence to antiretro­viral therapy in adult patients with HIV/AIDS. Keywords: Adherence, Antiretroviral therapy, HIV/AIDS, Disclosure of HIV status, Social support, Meta-analysis Correspondence:  Musta’inul Habibi. Masters Program in Public Health. Universitas Sebelas Maret, Jl.Ir. Sutami 36A, Surakarta 57126, Central Java. Email: Mustainul87@gmail.com. Mobile: 0856499­59811. Journal of Epidemiology and Public Health (2021), 06(01): 112-124 h ttps://doi.org/10.­26911­/jepublic­health.2021.06.01.11