Lung Involvement by Systemic Diseases

Systemic diseases commonly affect the lung, producing secondary pathology that can be difficult to recognize from primary lung diseases. These include pulmonary involvement by various autoimmune diseases such as relapsing polychondritis, rheumatoid arthritis involvement in the form of rheumatoid nodules, IgG4-related sclerosing disease, diseases that arise within compromised immune systems such as granulomatous lymphocytic interstitial lung disease (GLILD), and deposition diseases such as amyloid and light chain deposition disease. This chapter describes the clinical and pathology features of these six entities so that practicing pathologists recognize them.