Effect of of dexmedetomodine in total intravenous anesthesia: an observation on hemodynamics

Objective To observe the effect of dexmedetomodine(DEX)on hemodynamics during operation and in extubation period in minor surgery. Methods Forty patients (ASA Ⅰ -Ⅱ Scheduled for thyroidectomy under intravenous anesthesia were randomly divided into 2 groups, DEX group (group D) and control group (group N), with 20 patients in each. Midazolam, fentanyl, etomidate and cis-atracurium were used for rapid intravenous induction and remifentanyl, propfol, cis-atracurium were observed in BP and HR in both groups during extubation (P<0.05) .The SBP in group D raise from( 123±14) mm Hg( 1 mm Hg=0.133 kPa) to( 129±14) mm Hg,while in group N it was from( 123±10) mm Hg to( 139±15) mm Hg, the elevation of SBP in group D was significantly less than those of group N (P<0.05). The raise in RPP was much lower in group D then that of group N at the time of extubation and 1、5、10、30 mins after extubation. The score of extubation and the time for awake and extubation has no difference between groups. Conclusion DEX applied in minor operation under intravenous anaesthesia can diminished the fluctuation of hymodynamics, without significant influence on recovery time, extubation grade and complications. It was suitable to use DEX in minor operation under intravenous anaesthesia. Key words: Dexmedetomodine;  Total intravenous anaesthesia;  Minor surgery