Study The Risk Of Chronic Obstructive Pulmonary Diseases Among Successfully Treated Old Pulmonary Tubercular Cases By Measuring Lung Function Indices - A Hospital Based Case Control Multi Group Study

Background: Pulmonary tuberculosis consider as an independent risk factor for COPD by few recent researcher apart from tobacco smoke and biomass fuel though not much explored hitherto, therefore study conducted to find out possible association in between two epidemics of era. Methods: A hospital based multi group case control study was conducted in tertiary care centre of teaching institute by including 200 subjects comprises in four groups ,Group 1: 50 successfully treated non-smoker, non-biomass fuel smoke exposed, successfully treated patients of Pulmonary Koch’s, currently sputum negative. ; Group 2: 50 individuals with history of exposure to biomass fuel smoke. ; Group 3: 50 smokers, currently asymptomatic; Group 4: 50 normal (healthy) individuals, non smokers, non-biomass fuel smoke exposed and not having any history of tuberculosis.PFT was done in all included subjects. Data compiled and analyzed by using Standard statistical software spss23.p value <0.05 consider as significant. Results: Only 8(16%) subjects among old treated pulmonary tuberculosis having COPD (odd ratio= 2.19) contrary to this 14(28%) and12 (24%) subjects among smokers and biomass smoke exposed having COPD (odd ratio= 4.472; 3.63). However mean reduction in FEV1 % and FVC% in old tubercular group (55.33±25.46; 60.51±31.07) compare to healthy control (109.63±18.92; 94.89±12.94) was statistically significant (p=<0.05). Conclusion: Old pulmonary tuberculosis significantly associated with diminution of airflow in the lungs, as well as significant risk factor for COPD , though less in compare to tobacco & biomass smoke. [A Agrawal, Natl J Integr Res Med, 2018; 9(4):1-6]