Application of hierarchical nanostructured aluminum oxyhydroxide for bleeding control

In this work we studied the hemostatic action of hierarchical boehmite nanostructures (AlOOH) based on capillary and parenchymal bleeding in in vivo experiments. AlOOH nanostructures were obtained by oxidation of AlN/Al nanoparticles with water. This process resulted in the formation of mesoporous agglomerates of crumpled boehmite nanosheets with a thickness of 2–5 nm and a specific surface area of more than 280 m2/g. In experimental groups, the treatment of wounds with boehmite nanostructures was reported to almost half the time to stop bleeding. The bleeding control mechanism triggered by boehmite nanostructures may be associated with the aggregation of clotting factors on the nanostructure surface and the acceleration of fibrin clotting.