THU0125 IMPACT OF DISEASE ACTIVITY IN THE LEFT VENTRICULAR SYSTOLIC MYOCARDIAL FUNCTION OF PATIENTS WITH RHEUMATOID ARTHRITIS: A CASE-CONTROL STUDY

Background: Rheumatoid arthritis (RA) and dementia have a mechanism that systemic inflammation is involved in the onset, and its relationship can be predicted, but still controversy about the relationship between them. According to the prior literature, rheumatoid arthritis has reduced the risk of progression to Alzheimer’s disease (AD). Objectives: To investigate the risk of dementia in RA patients based on Korean National Health Insurance Service (NHIS) claim database Methods: We conducted a nationwide population-based study using a Korean NHIS consisted of 1 million individuals, who submitted medical care claims between 2002 and 2013. RA was identified using as the International Classification of Diseases code (ICD-10) M05 (seropositive RA) and dementia was defined as having a prescription of anti-dementia drugs with satisfying the AD (ICD 10 F00 or G30) or vascular dementia (VD, ICD 10 F1.0-1.3, F1.8 and F1.9) codes. The control groups were matched to the RA cohort by age and sex. Results: Of the total 6,028 dementia patients, 100 were diagnosed with RA. In patients with RA over 65 years of age compared to age and sex-matched control group, the dementia risk was shown as whole dementia OR 1.011 (95% CI, 0.811-1.260), AD 1.043 (0.826-1.318), Vascular dementia (VD) 1.274 (0.745-2.177). The sub analysis was performed by dividing the Charlson comorbidities index (CCI) into more than three (moderate) and less than (mild) groups. The mild groups were whole dementia OR 0.851 (0.468-1.546), AD 0.776 (0.392-1.536), VD 0.917 (0.126-6.673), and in the moderate group, whole dementia OR 0.961 (0.750-1.231), AD 0.939 (0.717-0.7) 1.230) and VD 1.219 (0.692-2.149). Conclusion: In conclusion, the risk of dementia in RA patents did not increase when compared to control group. Vascular dementia tended to increase in the RA group, but there was no statistical significance. Disclosure of Interests: None declared