A Platinum(IV) Prodrug - Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain.

Colin M. Fadzen,Justin M. Wolfe,Wen Zhou,Choi-Fong Cho,Niklas von Spreckelsen,Kathryn T. Hutchinson,Yen-Chun Lee,E. Antonio Chiocca,Sean E. Lawler,Ömer H. Yilmaz,Stephen J. Lippard,Bradley L. Pentelute

A Platinum(IV) Prodrug - Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain.

2020

Colin M. Fadzen
Justin M. Wolfe
Wen Zhou
Choi-Fong Cho
Niklas von Spreckelsen
Kathryn T. Hutchinson
Yen-Chun Lee
E. Antonio Chiocca
Sean E. Lawler
Ömer H. Yilmaz
Stephen J. Lippard
Bradley L. Pentelute

Effective delivery to the brain limits the development of novel glioblastoma therapies. Here we introduce conjugation between platinum(IV) prodrugs of cisplatin and perfluoroaryl peptide macrocycle...

Keywords:

Organic chemistry
Platinum
Cisplatin
Combinatorial chemistry
Glioblastoma
macrocyclic peptide
Peptide
Conjugate
Chemistry
Prodrug

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