Peptide Stability in Spray-Dried Powders for Inhalation

1. Gilchrist PJ, Bradshaw JP, Biochim Biophys Acta (1993) 1182:111-114. 2. Arvinte T, Cudd A, Drake AF, J. Biological Chemistry (1992) 268: 64156422. 3. Kamhira M, et al., Protein Science (2000) 9:867-877. 4. Lai MC, and Topp EM, J. of Pharmaceutical Sciences (1999) 88:489-500. 5. Pikal MJ, et. al., Pharmaceutical Research (1991) 8:427-436. 6. Duddu SP, Zhang G, Dal Monte PR, Pharmaceutical Research (1997) 14:596-600. • Salmon calcitonin used in these studies was obtained from Bachem AG (Torrance, CA). Stability samples were stored at 25°C at the relative humidities in the text.