A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC

APC is a well-known tumour suppressor that is frequently inactivated in colorectal cancer. Here, the authors sequence more than 1000 cancer genes in 468 colorectal cancers and show that mutation signatures can be used to classify the tumours and that multiple mutations in APC are associated with a poor prognosis.