Activité antipaludique d'une recette traditionnel utilisant une combinaison de plantes dans le traitement dupaludisme simple à plasmodium falciparum, à Agnanfoutou en Côte d'Ivoire

Introduction: The emergence and spread of modern antimalarial drug resistance render more difficult the therapeutic management of malaria. Faced with this situation, the availability of safe and effective traditional medicines could therefore emerge as an important alternative way to fight against this epidemic. The purpose of this study was to test the effectiveness of a traditional recipe used as local healers of malaria by village Agnanfoutou in Cote d'Ivoire. Materials and methods: This is a prospective and descriptive point of which focused on patients of any age with an axillary temperature greater than or equal to 37.5 ° C and symptoms suggestive of clinical malaria with a thick smear positive Plasmodium falciparum with a parasitemia greater than or equal to 1,000 trophozoites per microliter of blood. The treatment administered consisted of seven plants used in combination. It was Adenialobata (Jacq) Engl, Aframomumsceptrum(Oliv. and Hamber.) K. Schum, Harunganamadagascariensis.Lam., Hoslundiaopposita Vahl (Benth.) Bak.,Tremaguineensis (Schum. and Thonn.) Ficalho and Vernoniacolorata (Willd.) Drake. Treatment was administered by subcutaneous (bath friction on the body), oral (drinking), rectal (enema) and eye (instillation). Patients who adhered to our protocol were subjected to clinical and parasitological regularly to assess the evolution of thermal and parasitological clearance and detect any signs of intolerance. Results: Fifteen patients with a positive thick all were included in the study and 13 were evaluable at the final analysis. Two were excluded, respectively J7 and J10 for having developed signs of gravity during treatment. The reasons for consultation were dominated by fever, shivering and dying dark urine which was present in all patients (100%). The average temperature at baseline (D0) was 39.2°C ± 0.49°C versus 36.9 ± 0. 35° at the end of follow-up period. As for the average parasitemia, it was of 9 123 ± 4 830 trophozoites per microliter of blood at baseline versus 0 at the end of follow-up period. After 15 days of treatment, clinical and parasitological cure was obtained in 100% of cases. No cases of intolerance were observed. Conclusion: The combination of plants used by traditional healers to Agnanfoutou has an effect on the efficiency uncomplicated Plasmodium falciparum. However, other studies using larger samples and further pharmacological studies are still needed to optimize the use den.