Abstract 13416: Phospholipase cβ1b Depletes Sarcoplasmic Reticulum Calcium Content and Causes Cardiac Contractile Dysfunction

Phospholipase Cβ1b (PLCβ1b) is the immediate effector of Gq and Gq-coupled receptors (α1-adrenergic-, endothelin- and angiotensin II- receptors). Dilated atria from humans, mice and sheep show heig...