Concordance in cervical HPV detection between hybrid capture 2 and HPV GenoArray tests.
2014
Abstract HPV type-specific detection may promote cervical screening program and vaccination development worldwide. We conduct a study comparing HPV Hybrid capture II (HC II) Test and Hybribio GenoArray test, a newly developed HPV type-specific assay, in patients with cervical epithelial neoplasm. Results showed a good concordance in cervical HPV detection between two tests (kappa value 0.80, p <0.05, McNemar test). Our study may promote utilization of type-specific HPV detection that is helpful for cervical cancer screening and vaccination. Keywords: Human papillomavirus - cervical cancer - hybrid capture RESEARCH ARTICLE Concordance in Cervical HPV Detection between Hybrid Capture 2 and HPV GenoArray Tests Li Zhang 1 , Yong Lin 2 , Jin-ke Li 1 * Ethical Commmittee and informed consent was obtained from the patients. Cohen’s kappa statistics and the nonparametric McNemar test were used for statistical analysis. Statistical significance was assumed at p <0.05. Results High-risk HPV detection rate was 77.3% (85/110) and 73.6% (81/110) by HC2 test and GenoArray test in CIN patients, respectively. The overall agreement in high-risk HPV detection between the two assays was 92.9% with the kappa value of 0.80 (
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