A case of crescentic glomerulonephritis associated with relapsing polychondritis
2018
Relapsing polychondritis (RP) is a rare autoimmune disease, characterized by recurrent
inflammatory episodes affecting various carttilageus structures. Renal involvement in RP is
unusual. Our case was a 42-year old woman presented with nephretic syndrome. Diagnosis
of RP was made because of recurrent chondritis of both auricles, chondritis of costovertebral
joints, non-erosive inflammatory arthritis of knees, and inflammation of ocular structures.
Renal biopsy findings revealed diffuse crescentic and sclerotic glomerulonephritis, pauciimmune
type. The diagnosis of RP may be missed when the destructive cartilage feature is not
apparent or rare presentation of disease such as ocular or renal involvement preceded other
manifestations. In this case we found that the irregular prednisolone use may prevent destructive
cartilage damage but not renal failure of patient. We concluded that the association of crescentic
glomerulonephritis in a patient with RP was assumed to be a rare manifestation of this disease.
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