The levels of interleukin-6, interleukin-10 and tumor necrosis factor α in serum and broncholveolar lavage fluid of children with adenovirus pneumonia and its clinical significance

Objective To detect the levels of interleukin-6(IL-6), interleukin-10(IL-10) and tumor necrosis factor-α(TNF-α) in serum and broncholveolar lavage fluid of children with adenovirus pneumonia, and compared with the healthy control group, and to explore the correlation with the clinical manifestations of adenovirus pneumonia. Methods Enzyme linked immunosorbent assay(ELISA) was used to detect IL-6, IL-10 and TNF-α levels in serum and bronchoalveolar lavage fluid of 40 children with adenovirus pneumonia and 20 healthy control children. Results The levels of IL-6, IL-10 and TNF-α in serum and bronchoalveolar lavage fluid of 40 children with adenovirus pneumonia were significantly higher than the control subjects(all P<0.05). In addition, the levels of IL-6, IL-10 and TNF-α in serum and bronchoalveolar lavage fluid of children in the acute phase were significantly higher than children in the recovery phase[(47.5±17.7)pg/mL vs.(22.3±6.5)pg/mL; (7.5±1.3)pg/mL vs.(5.3±2.1)pg/mL; (123.4±5.3)pg/mL vs.(71.3±5.4)pg/mL], the differences were statistically significant(t=7.57, 8.39, 11.57, all P<0.05). Conclusion The levels of IL-6, IL-10 and TNF-α in peripheral blood and bronchoalveolar lavage fluid of children with adenovirus pneumonia increased significantly, suggest that IL-6, IL-10 and TNF-α may play important roles in the incidence of adenovirus pneumonia in children. Key words: Pneumonia; Adenoviridae infections; Interleukin-6; Interleukin-10; Tumor necrosis factor α