Critical Aspects to be Considered Prior to Large-Scale Production of Peptides
2013
Numerous peptides are available on the market as therapeutic drugs for regulating tumor growth, microorganism
proliferation, immune response and/or metabolic disorders. Peptides are produced either by chemical synthesis or heterologous
expression. Independent of the method chosen, there are challenges to transferring its production from the
bench (~mg/L) to the industrial (~g/L) scale. Thus, the main scale-up pitfalls for the two methods of peptide production
are reviewed here, including the advantages of each. Moreover, there will be a special focus on the main challenges for
large-scale, heterologous production systems. Peptides that are currently available on the market are also described with
an emphasis on how their process optimization has been designed in order to develop a cost-effective product.
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