Effect of modulation of CD3 binding in a PSMAxCD3 T-cell engaging bispecific antibody on maintenance of efficient tumor cell kill and cytokine release.

Ben Buelow,Kevin Dang,Pranjali Dalvi,Yuping Li,Alexander Cheung,Chiara Rancan,Preethi Sankaran,Duy Pham,Katherine Harris,Laura Davison,Aarti Balasubramani,Starlynn Clarke,Alec Starzinski,Lawrence Fong,Suhasini Iyer

Effect of modulation of CD3 binding in a PSMAxCD3 T-cell engaging bispecific antibody on maintenance of efficient tumor cell kill and cytokine release.

2020

Ben Buelow
Kevin Dang
Pranjali Dalvi
Yuping Li
Alexander Cheung
Chiara Rancan
Preethi Sankaran
Duy Pham
Katherine Harris
Laura Davison
Aarti Balasubramani
Starlynn Clarke
Alec Starzinski
Lawrence Fong
Suhasini Iyer

e17583Background: Castration resistant prostate cancer (CRPC) is an incurable disease and represents a significant unmet need. Prostate specific membrane antigen (PSMA) is a protein highly expresse...

Keywords:

Cytokine
CD3
tumor cells
Pathology
Medicine
T cell
Cancer research
bispecific antibody

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