The altered expression of Paraoxonase 1 in the gastric carcinoma.

94Background: High doses inadequate removal of reactive oxygen species result in oxidative stress, which may cause severe metabolic malfunctions and damage to biological molecules including DNA An elevated oxidative status has been found in many types of cancer cells and helicobacter infection. Paraoxonase 1 is one of the endogenous free radical scavenging systems in the human and believed to be involved in the protection against oxidative stress. It has been reported that serum levels of Paraoxonase 1 were lower in patients with pancreatic or gastric cancer than in healthy controls. But there was no study about differential Paraoxonase 1 expression in gastric cancer tissue compared to adjacent non-tumor tissue. In this study, we investigated the changes of Paraoxonase 1 expression in the helicobacter pylori infection and gastric cancer. Methods: 109 gastric cancer tissues and 109 adjacent non-tumor tissues were obtained from 109 patients who received gastrectomy for curative resection. Eighteen H. pylori...